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This article presents a professionalization framework to address the shortage of skilled health supply chain management (SCM) workers. Developed through interviews with experts, the framework includes a competency library, job descriptions, educational mappings, and an implementation guide. It helps countries standardize and enhance the SCM workforce, particularly in low- and middle-income countries, ensuring workers have the necessary skills and qualifications to manage health commodities effectively. The article was originally published in the Global Health: Science and Practice journal, Vol. 12, No. 4, available at https://www.ghspjournal.org/content/early/2024/08/20/GHSP-D-23-00119.